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Literature summary extracted from

  • Wang, R.; Zhang, T.; Ma, Z.; Wang, Y.; Cheng, Z.; Xu, H.; Li, W.; Wang, X.
    The interaction of coagulation factor XII and monocyte/macrophages mediating peritoneal metastasis of epithelial ovarian cancer (2010), Gynecol. Oncol., 117, 460-466.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.38 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.38 epithelial ovarian cancer cell
-
 Homo sapiens
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3.4.21.38 ES-2 cell
-
 Homo sapiens
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3.4.21.38 SKOV-3 cell
-
 Homo sapiens
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Synonyms

EC Number Synonyms Comment Organism
3.4.21.38 coagulation factor XII
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 Homo sapiens
3.4.21.38 FXII
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 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.21.38 malfunction interaction between FXII and monocyte/macrophages contributes to epithelial ovarian cancer cell invasion and metastasis of the peritoneum. After FXII treatment the cells exhibited M2-polarized phenotypes and show upregulated phagocytic potential. Transcription factors including Fra-1, Fra-2, Fos-B in the AP-1 family, oncogenes HIF-1 and Oct, and STAT-5A in the STAT family are upregulated in FXII-stimulated monocyte/macrophages Homo sapiens